Science has developed so far and with the help of available techniques and procedures, it has become quite easy to knock down many disease conditions and other congenital conditions occurring in human lives. Techniques developed till now have really worked well in improving lives. There are many techniques that are being into developing stage and enthusiasts are working hard on it to make it possible to pin down every possible disease and other ailment conditions. One such congenital condition is called, cleft lip and cleft palate. It affects 1 in every 600 children born worldwide (1) and is one of the most commonly occurred congenital deformities. It has been explained and shown the particular gene playing role in sole or in association with other factors playing role in the formation of non-syndromic cleft lip and/or cleft palate. Several genes has been found and sequenced for confirmation and found playing role in formation of different forms of cleft lip and/or cleft format.